Napoli, the former Angels catcher who was traded away after the 2010 season, went five for nine with four homers and eight runs batted in during the three-game series, including two homers in Saturday night's 8-3 win.
The slugger now has a .333 career batting average (55 for 165) with 18 homers and 36 runs batted in against the Angels.
Sunday’s homer, off Angels starter
Napoli was intentionally walked with first base open in the sixth, but with two on in the eighth, he drove a two-run double high off the Green Monster in left-center for a 5-1 lead. Brock Holt followed with an RBI single for a 6-1 lead.
Santiago (3-3) took the loss despite maintaining his stuff over 6 2/3 innings in which he allowed three runs and seven hits, struck out six and walked one with a career-high 124 pitches.
The Angels, who finished 5-5 on a 10-game trip to Baltimore, Toronto and Boston, managed only one run and four hits in eight innings off Red Sox left-hander
Boston pushed the lead to 3-0 in the fifth when Holt doubled to right-center, took third on Sandy Leon’s sacrifice bunt and scored on
The Angels cut the deficit to 3-1 in the sixth when