Lange was in New Orleans for Super Bowl media day Tuesday, and played part of the interview on his syndicated radio show that night.
"I don't do the gay guys man," Culliver said in response to gay players in the NFL. "I don't do that."
Lange asked if he thought there were any gay players currently on the 49ers.
"No, we don't got no gay people on the team, they gotta get up out of here if they do. Can't be with that sweet stuff."
So Lange asks if gay players would need to keep it a secret.
"Yeah, come out 10 years later after that," Culliver said.
Yahoo Sports was first to report this story. You can listen to the Culliver interview there.