The game at StubHub Center in Carson starts at 7 p.m. The second game is scheduled in Tijuana on March 18.
CONCACAF is a federation of club teams mainly from North America and Central America.
The Galaxy advanced to the quarterfinals by compiling a 3-1-0 record in the initial group-stay play against Isidro Metapan of El Salvador and CS Cartagines of Costa Rica.
If the Galaxy prevails in the two-game, aggregate-goal series against Club Tijuana and advances to the semifinals, it would face the winner of the quarterfinal series between