The junior running back also had five touchdowns among his 39 rushes for the Tigers (12-2), who advance to the semifinals of college football's second tier formerly known as Division I-AA. The Panthers finish the season at 12-2.
The 354 yards by West eclipsed the former record of 333 yards by Georgia Southern's
"If you picture big plays, you make big plays," West said after the game. "So I was picturing."
West, who helped lead the Tigers to a 33-18 victory over Connecticut in the season opener, also established a new FCS record for rushing touchdowns in a season with 38, breaking the mark of 35 by Omar Cuff of Delaware in 2007.
And West is now the new single-season rushing leader in FCS history with 2,347 yards, surpassing the 2,326 yards of Colgate's Jamaal Branch in 2003.