Five players scored in double figures for the Bruins (6-0), who quickly erased an early five-point deficit and built a double-digit lead less than 10 minutes into the game.
UCLA's lead got as high as 19 in the first half, when the Bruins shot 16 of 25 (64%) from the field and 17 of 18 at the free-throw line. They finished at 60.7 percent from the floor, including 10 of 20 from 3-point range.
Deonte Burton and Jerry Evans Jr. each scored 20 points for Nevada (3-4), while Michael Perez added 18.
UCLA will play Northwestern on Friday, and the Wolf Pack will face Missouri.
It was the second consecutive 100-point game for the Bruins, who beat Chattanooga, 106-65, on Sunday.
After falling behind 7-2 only 2 minutes into the game, UCLA scored nine consecutive points in a 16-4 run to pull ahead 18-11 at the 13:06 mark. LaVine hit a pair of three-pointers to spark the first spurt. The freshman guard scored 10 of UCLA's first 25 points to help the Bruins extend their lead to 10 points midway through the first half.
The Wolf Pack refused to go away, scoring the next four points to cut the lead to 25-19. But that was the closest they would get the rest of the game. Adams quickly ended Nevada's mini-run with a 3-pointer, then the Bruins went on a 10-for-10 run from the free throw line to go back up by 12 with 5:29 left.
David Wear scored the Bruins' final nine points of the half to give UCLA a 56-39 lead at the break.