USC defeated the Sooners, 4-2, to win its 21st men's title.
The Trojans finished 32-3 and won their fifth title in six years.
"We've had so many great players, and it's amazing to see a new group stepping up," Coach Peter Smith told the Associated Press. "Winning one of these is so hard."
Oklahoma won two doubles matches to earn a point before USC came back to win. USC clinched the title when Max de Vroome won No. 4 singles.
Ray Sarmiento, Yannick Hanfmann and Eric Johnson also won singles matches for the Trojans at the Dan Magill Tennis Complex.