The Trojans won the 400-yard relay Saturday night, which helped them complete the meet with 278 points.
Texas won its 11th title with 528 points, California was second with 399, Michigan third with 312.
USC's Cristian Quintero, Santo Condorelli, Raif Tribunstov and Dylan Carter teamed to win the 400 relay.
Quintero won the 200-yard freestyle and also was part of the winning 800-yard relay. He finished fifth in the 500 and third in the 100.