"I know that watching TV is only going to frustrate him," Simpson told the syndicated TV show "Extra" for a segment scheduled to air Thursday.
Simpson also advised Blake against taking a lie detector test and added, "As far as I'm concerned, this man is innocent until a jury comes back and calls him guilty."
Blake's wife, Bonny Lee Bakley, 45, was shot to death May 4 in her husband's car after the couple dined at a Studio City restaurant. Police have said that no one has been ruled out as a suspect.
Blake, who married Bakley four months ago after DNA tests proved he fathered her 11-month-old daughter, has said she was shot while he returned to the restaurant to pick up a gun he left behind. He said he was carrying the gun because Bakley had expressed concerns about her safety.
Blake's son, appearing Wednesday on CNN's "Larry King Live," defended his father and said Bakley "was afraid and wanted him to carry it," Noah Blake said.
"My dad is innocent, period," Noah Blake said. "He doesn't need to prove that. He is not obligated nor is he obliged to address a thousand-trillion rumors."