The price of losing Wise will depend on whether his teammates will produce as resourcefully as they did with a 16-hit attack en route to a 10-6 victory over the Tigers at chilly Comerica Park.
Although Wise lost his leadoff duties with an 0-for-8 start, he was five for his last 11, and his catch in right-center field robbed Ramon Santiago of a two-run, extra-base hit in the fifth inning with the Sox trying to protect an 8-4 lead.
"I feel sorry for the kid, but you've got to move on, and hopefully a guy is coming that can help us," manager Ozzie Guillen said.
That will be Jerry Owens, 28, who was 1-for-7 at Triple-A Charlotte, was beaten out by Wise for center field/leadoff duties, cleared waivers and had been questioned by Guillen for not showing more intensity.
General manager Ken Williams recalled Owens, but Guillen indicated Brian Anderson would get the first shot at replacing Wise.
"I need a true center fielder," Guillen said. "Hopefully Brian does the job. If not, I'll give Jerry a shot."
Anderson replaced Wise and drew two walks and stole two bases.
"If I'm in there, good," said Anderson, who was saddened by the loss of Wise. "If I'm not, good luck to the guy who is in there."
After the game, Wise returned to Chicago to undergo more tests. But right fielder Jermaine Dye knew Wise was seriously injured after making the diving catch.
"There was a knot, and I had the same thing happen to me before," Dye said.
The catch came before Gavin Floyd walked his seventh batter and allowed a two-run double to Josh Anderson.
But in the top of the sixth, Carlos Quentin hit his second home run of the game, fourth in his last four games.
Dye and Konerko, who reached the 300-career home run mark in consecutive at-bats in the second, hit back-to-back doubles in the sixth to stretch the lead to 10-6.
Reliever D.J. Carrasco pitched two scoreless innings, and third baseman Josh Fields made a diving stop to retire Carlos Guillen with runners at first and third to end the eighth.
The Sox also manufactured four runs in the third without the aid of a homer.
"We know we're going to hit," Guillen said. "It was just a matter of time, but in the meanwhile we created a couple of runs. Two home runs, three home runs, fine, but after that we created more runs. We weren't chasing bad pitches and took advantage of that."