But prosecutors say the former soldier kept dark secrets while spreading God's word.
Hopkins, 39, was arrested in 2008 while preaching a rural revival in Clarke County.
A teenage relative allegedly pregnant with his baby led police to the body of 36-year-old Arletha Hopkins, a mother of eight ranging in age from an infant to late teens.
Investigators say Hopkins killed his wife in 2004 after she caught him having sex with a female relative, then stuffed her body into a freezer at the Mobile home he shared with her, six children and two stepchildren.
Nicholas L. Jackson Sr., pastor of a small church in Jackson where Hopkins sometimes preached, told a local newspaper in 2008 that many who heard him considered him a prophet with psychic abilities.
"When he told you something was going to happen, you could pretty much count on it," he said.
He described Arletha Hopkins as quiet.
Authorities have said the children were home-schooled and largely kept out of sight of neighbors and others in the community.
Hopkins told some church associates that his wife had died in 2004 giving birth to their youngest child.
He faces life in prison. He looked on attentively during jury selection, making frequent and lengthy eye contact with jurors, taking notes and conferring with his attorneys as about 60 potential jurors were questioned during the selection process that began Monday.
One said she watched Hopkins and several of his daughters perform as part of a family musical group at a religious event a few years ago. Several others said they had attended churches with ties to Hopkins.
Only four said they had not heard or read news reports about the case.
Assistant District Attorney Ashley Rich said several of Hopkins' young female relatives are expected to testify during a weeklong trial.
"It is a very sensitive, emotionally difficult type of case," she said.
Hopkins was previously arrested in Saraland, near Mobile, in 1998 for being absent without leave from the U.S. Army in Fort Bragg, N.C., from June 15, 1995, until April 6, 1998.
It is unclear how military authorities resolved the case and attorneys declined to answer questions about Hopkins' background Monday, saying Circuit Judge John Lockett had ordered them not to discuss the case with media.
Prosecutors have previously said Hopkins has no steady employment record and has ties to Alabama, Georgia, Mississippi,
Texas and North Carolina through his time in the military and his church work.
He lived in Mobile for about eight years before his arrest, working for about four years as a nurse's aid at a state mental facility and four years at a ship yard.