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Tsvetana Pironkova

Williams sisters lose at the French Open

Williams sisters lose at the French Open

PARIS — Wind was whipping, rain was falling, and thick gray clouds overhead were foreboding as Serena Williams double-faulted, then raised her hands in despair and wailed, "I can't serve!"

As if to prove the point, Williams double-faulted again moments later, before pushing a routine backhand wide to get broken at love.

Truth is, the defending French Open champion couldn't do much right Wednesday afternoon, absorbing the most lopsided loss of her 288-match Grand Slam career. Unable to figure out how to get herself going or counter her unheralded opponent's aggressive game, Williams was beaten, 6-2, 6-2, by 35th-ranked Garbine Muguruza of Spain in the second...