Katherine Heigl

Katherine Heigl

Katherine Heigl has had difficulties with love on "Grey's Anatomy," but that's nothing compared to the plight of her character in the upcoming romantic comedy "27 Dresses."

According to Variety, Heigl has signed on to play a woman who has experienced the honor of being a bridesmaid on 27 occasions. Her latest bridesmaid gig is for her sister, who happens to be marrying the man that the bridesmaid loves.

The film, financed by Spyglass, will be directed by "Step Up" helmer Anne Fletcher from a script by Aline Brosh McKenna ("The Devil Wears Prada") with a polish by Dana Fox ("The Wedding Date"). Shooting will begin in May in New York and Rhode Island.

Strangely, this is the second bridesmaid-themed project on tap for the stars of ABC's hit medical drama. Patrick Dempsey plans to use his hiatus to star in "Made of Honor," a romantic comedy about a man asked to be maid of honor at his female best friend's (Michelle Monaghan) wedding.

Heigl is currently attracting ample buzz for her summer comedy "Knocked Up," a Universal comedy from director Judd Apatow. Her other feature credits include the notoriously low grossing "Zyzzyx Rd." and the pervy classic "My Father the Hero."