The 62-year-old actress proved to be a game-changer when she starred for nine years and 224 episodes as Roseanne Conner on the TV show "Roseanne" in the 1990s. Barr returned to her stand-up roots in 2013 with a headline act at the Tropicana in Las Vegas.
And now she lands at the Venetian. Those who want to catch her comedy on a more frequent basis can catch her daily blog on her personal website or as the center judge on "Last Comic Standing."
Back in the 1990s, Entertainment Weekly called "Roseanne" "the most ground breaking kitchen-sink sitcom since 'All in the Family' " and gave her props for turning her experiences as a wife and a mother into comedy fodder.
But what has she done lately? The Salt Lake City native guest starred on "The Office," "Portlandia" and "The Millers." She also has her own talk show, "The Roseanne Show," which earned her a Daytime Emmy Award nomination as outstanding talk show host.
Little do fans know that in the past she even has appeared on three episodes of the soap opera "General Hospital" as Jennifer Smith, who broke off her engagement to Luke Spencer, in 1994.
On the big screen, she's appeared in "She Devil," "Freddy's Dead," "Blue in the Face" and "Meet Wally Sparks." She also has voiced characters in "Look Who's Talking Too" and "Home on the Range."
And she's an author of three books: "Roseanne: My Life as a Woman," "My Lives" and most recently, "Roseannearchy: Dispatches from the Nut Farm." The Lifetime cable TV series "Roseanne's Nuts," which she also executive produced, followed Barr as she ran a nut farm in Hawaii.
Tickets to the live show at the Venetian start at $50.