1. "Contagion" - $20 million

Steven SoderberghGwyneth PaltrowMatt Damon
Matt Damon and Gwyneth Paltrow lead a major cast in this Steven Soderbergh thriller about a killer virus that quickly spreads all over the planet. Are people going to come out in droves for a movie about panic? We'll see, but with it opening on 3,100 plus screens, I'm guessing it'll pull $20...