The Jerry Bruckheimer-produced feature will be the directing debut of Oscar-winning visual effects man Hoyt Yeatman ("The Abyss").
The project, which has no connection to the comic "WE3," but sound like it ought to, is about a group of animals who have been engineered into ultra-intelligent commandos. The animal-soldiers are enlisted to stop an evil billionaire. According to The Hollywood Reporter, Cage will voice a mole named Speckles, Buscemi a hamster named Bucky and Morgan will voice the guinea pig Blaster.
On board for the human side of the story are Bill Nighy, Will Arnett, Zach Galifianakis, Kelli Garner, Gabriel Casseus and Jack Conley.
Production has already begun in Los Angeles.
Cage was most recently seen in "Next" and "Ghost Rider," while Buscemi's 2007 credits include "Interview," "I Think I Love My Wife" and "I Now Pronounce You Chuck and Larry."
"SNL" vet Morgan currently co-stars in NBC's Emmy-winning "30 Rock."