Joining Combs in the adaptation of the BBC format are Brooke Burns and Rochelle Aytes, according to The Hollywood Reporter.
"Mistresses" focuses on a quartet of female friends from college now facing life in their thirties.
Combs' character gave up a career to be a stay-at-home mom. Burn will play a successful attorney and Aytes is a soap star.
In addition to her long run as Piper on "Charmed," Combs' credits include "Picket Fences" and the cinematic classic "Dr. Giggles."
Burns' was one of the stars of ABC's short-lived comedy "Miss Guided," which joins the equally short-lived "North Shore" and "Pepper Dennis" on her resume.
Aytes was last seen on FOX's "Drive."