Jackson will play a doctor on the ABC series. His first appearance is scheduled for the show's 11th episode, which barring a writers strike will likely air in December or January.
In other casting news, Variety reports that Carrie-Anne Moss ("The Matrix") will star opposite Joseph Fiennes in FX's pilot "Pretty Handsome," and Larenz Tate ("Rescue Me") has joined the cast of NBC's drama pilot "Blue Blood."
Additionally, Megan Dodds and Christina Vidal have joined an NBC legal drama from writer Luke Reiter, according to The Hollywood Reporter.
Jackson's stint on "Grey's Anatomy" will be his first TV role since "Dawson's Creek" ended its run in 2003. His recent movie credits include "Bobby" and the forthcoming "Shutter" and "Battle in Seattle," both of which are scheduled for release early next year.
In "Pretty Handsome," from "Nip/Tuck" creator Ryan Murphy, Moss will play the wife of a doctor (Fiennes) who undergoes a sex change. In addition to the "Matrix" trilogy, Moss has appeared in "Memento" and "Disturbia."
At NBC, Tate joins Logan Marshall-Green in "Blue Blood," about a group of rookies in the NYPD, one of whom (Marshall-Green) is a Harvard graduate. In the Reiter pilot, Dodds ("MI-5") will play an attorney caught up in a love triangle with two colleagues (Alan Tudyk, Andrew Lincoln). Vidal ("I Think I Love My Wife") will play a law student who works as Lincoln's assistant.