Paddy Considine ("Hot Fuzz," "Cinderella Man") and Jonathan Pryce ("Pirates of the Caribbean: At World's End") will also star in the film, which HBO is co-producing with the BBC. It's likely to premiere sometime in 2008.
"This is further proof that great writing attracts great talent," HBO Films president Colin Callender says. "We are thrilled to be working with David Hare -- he truly is a writer in a league of his own. It is a testament to his provocative script, and to director Anthony Page, that we have been able to bring together such a wonderful cast of distinguished actors."
"The Zinc Bed," which debuted in London in 2000, centers on Considine's character, an alcoholic who becomes involved with his boss' wife (Thurman). Through their affair, the play explores the ideas of "addiction and obsession," HBO says.
The movie will be Thurman's second project for HBO; she won a Golden Globe in 2003 for her performance in "Hysterical Blindness." The "Kill Bill" and "My Super Ex-Girlfriend" star has two feature film projects due in the next year, "In Bloom" and "The Accidental Husband."
Considine will next be seen in "The Bourne Ultimatum," due in theaters in August. Two-time Tony Award winner Pryce's credits include "Evita," "The New World" and HBO's "Barbarians at the Gate," for which he scored an Emmy nomination.
Hare earned an Oscar nomination in 2003 for his adaptation of "The Hours." Among his screen credits are "Plenty," "Strapless" and "Wetherby." Director Page has a long list of stage credits to his name, along with TV adaptations of "Middlemarch" and "The Missiles of October."