T.R. Knight (George O'Malley) of 'Grey's Anatomy'

The good-under-pressure, and all-around "good guy/best friend" George O'Malley saved his last life this past season on "Grey's Anatomy." In saving a woman from a speeding bus, he was flattened and now with news that T.R. Knight's contract wasn't renewed, we're left with an exit that only George... ABC