Kamau Stokes scored 15 points and Kansas State held off a late rally to hand No. 2 Baylor its first home loss of the season, 56-54, on Saturday in Waco, Texas.
Stokes made both of the Wildcats' field goals in the final 6:29, including a baseline jumper with 1:40 to go off an inbounds pass with one second left on the shot clock that made it 55-51.
Baylor's Johnathan Motley missed two shots in the final seconds with a chance to tie the game, the latter of which was blocked by D.J. Johnson of the Wildcats (16-7, 5-5 Big 12) as time ran out and the Bears lost their second consecutive game.
Motley led Baylor (20-3, 7-3), which lost 73-68 at No. 3 Kansas on Wednesday, with 17 points and 14 rebounds, but he made only six of 17 shots from the field.
Iowa State 92, at No. 3 Kansas 89: Deonte Burton hit seven three-pointers and scored 29 points, Monte Morris added 25 and the Cyclones rallied from a big halftime deficit to end the Jayhawks' 51-game winning streak at Allen Fieldhouse.
Naz Mitrou-Long added six three-pointers and 22 points for the Cyclones (14-8, 6-4 Big 12), who had a school-record 18 three-pointers while forcing the Jayhawks (20-3, 8-2) into 21 turnovers.
They also overcame a monster performance by the Jayhawks' Frank Mason III, who had a career-best 32 points while going 9 of 11 from the field, 4 of 5 from beyond the arc and 10 of 12 at the free throw line.
The Cyclones ran off their bench to celebrate a stunning victory. It came on the heels of back-to-back losses for Iowa State, and back-to-back wins by the Jayhawks over No. 8 Kentucky and No. 2 Baylor.
at No. 1 Gonzaga 90, Santa Clara 55: Jordan Mathews scored 16 points, Josh Perkins had 15 and the Bulldogs extended the nation's longest winning streak to 24 games.
Zach Collins added 14 points and eight rebounds in Gonzaga's first-ever home game as the nation's top-ranked team. While several top-25 teams stumbled throughout the day, the Zags (24-0, 12-0 West Coast) shot 60% from the field and were in control almost right from the start.
KJ Feagin scored 18 points and Jared Brownridge had 13 for Santa Clara (13-12, 7-5) which lost at home to Gonzaga by 31 points in mid-January. It has dropped 14 consecutive games against the Bulldogs.
at No. 4 Villanova 92, St. John's 79: Josh Hart had 26 points and nine rebounds, Donte DiVincenzo scored a career-high 20 points and the Wildcats earned their third consecutive win. Kris Jenkins added 15 points for Villanova (22-2, 9-2 Big East), and Mikal Bridges had 14 points.
Marcus LoVett led St. John's (11-14, 5-7) with 23 points, and Bashir Ahmed had 15 points and seven rebounds before fouling out with 8:18 left. Shamorie Ponds also had 15 points for the Red Storm, who have lost 14 in a row against the Wildcats.
Oklahoma State 82, at No. 7 West Virginia 75: Phil Forte scored all 13 of his points in the second half to lead the Cowboys to the road win. Oklahoma (15-8, 4-6 Big 12) has the league's longest current winning streak at five after No. 2 Baylor and No. 3 Kansas both lost on Saturday.
West Virginia (18-5, 6-4) had a chance to move into a second-place tie with Baylor but couldn't match Forte's production down the stretch.
Forte scored nine points over the final five minutes. Jeffrey Carroll led the Cowboys with 20 points, but he had only three after halftime, and Jawun Evans added 18.
Evans' driving layup put Oklahoma State ahead to stay, 71-69, with 4:17 left, and Lindy Waters' three-pointer and four free throws by Evans put the Cowboys up 78-74. Forte sealed the win by making all four of his free throw attempts in the final minute.
Redshirt freshman Lamont West scored a season-high 21 points for West Virginia and Tarik Phillip added 15.
No. 6 Louisville 90, at Boston College 67: Deng Adel scored a career-high 19 points, and Donovan Mitchell also had 19 as the Cardinals won for the seventh time in eight games.
Mangok Mathiang scored 16 points and Ray Spalding and Jaylen Johnson had seven rebounds apiece for the Cardinals (19-4, 7-3 Atlantic Coast Conference). Louisville's last four wins have come by an average of 33 points.
Ky Bowman scored 18 points and added five rebounds for BC (9-15, 2-9). The Eagles have lost nine of their last 10 games.
at No. 24 Florida 88, No. 8 Kentucky 66: Kasey Hill matched a career high with 21 points, Devin Robinson added 16 and Gators Coach Mike White got the breakthrough win he wanted.
Florida (18-5, 8-2 Southeastern Conference) ended a five-game losing streak in the series and picked up its first win in four tries against ranked teams this season. Florida improved to 2-10 against ranked teams under White, winning for the first time since upsetting West Virginia in January 2016.
Canyon Barry chipped in 14 points and KeVaughn Allen finished with 12 for the Gators, who outran the Wildcats (18-5, 8-2) up and down the court.
at Syracuse 66, No. 9 Virginia 62: Tyus Battle had a career-high 23 points, Andrew White also had 23 and the Orange beat a ranked team for the second time in eight days.
Syracuse (15-9, 7-4 Atlantic Coast Conference) extended its winning streak to four games and remained in the hunt for the postseason. The Orange beat Florida State 82-72 last Saturday.
Kyle Guy had 14 points for Virginia (17-5, 7-3 ACC), which failed to move into a tie with North Carolina for the conference lead.
The victory would have been the 1,000th for Syracuse Coach Jim Boeheim, but the NCAA stripped him of 101 victories as part of punishment handed down in 2015 after a multiyear investigation of the school's athletic department. That leaves Boeheim at 899, three shy of matching Bob Knight for second place all-time behind Duke's Mike Krzyzewski.
at No. 14 Cincinnati 82, Connecticut 68: Kyle Washington scored a career-high 27 points, and Gary Clark had his fifth double-double of the season as the Bearcats won their 14th in a row.
Cincinnati (21-2, 10-0 American Athletic) never trailed while winning its 22nd in a row at home, extending its longest overall winning streak in three years. Washington had 13 of Cincinnati's first 17 points as the Bearcats got the early advantage. Clark had 20 points, 11 rebounds and three assists.
Rodney Purvis scored 20 points for UConn (10-12, 5-5), which had won its last three games.
No. 23 Purdue 73, at No. 17 Maryland 72: Carsen Edwards made two free throws with 2.1 seconds left to finish the Boilermakers' rally and knock the Terrapins out of first place in the Big Ten.
After Purdue took a timeout to set up a play, Edwards was fouled on a drive to the basket and calmly sank both shots. Maryland freshman Kevin Huerter then hit the rim on a jumper from the corner, leaving Purdue to celebrate its first road win over a ranked opponent since 2013.
The Terrapins (20-3, 8-2) didn't make a basket over the final 7 1/2 minutes, scoring their final 14 points at the free throw line — including 11 by Melo Trimble.
Caleb Swanigan scored 26 points for the Boilermakers (19-5, 8-3), who trailed by 12 in the second half. Purdue has won five of six.
No. 18 Saint Mary's 71, at San Diego 27: Calvin Hermanson and Jock Landale each scored 14 points for the Gaels (21-2, 11-2 West Coast Conference), who limited the Toreros to just nine field goals.
Saint Mary's, which has won six in a row, shot 51% (26 of 51) from the field, compared to 19.6% (nine for 46) for San Diego. Olin Carter III led the Toreros (11-13, 4-8) with 11 points. None of his teammates had more than three points.
at No. 19 South Carolina 77, Georgia 75: PJ Dozier scored seven of his 21 points in the final 2:21 as the Gamecocks finished off their first regular-season sweep of Georgia in eight years.
South Carolina (19-4) also maintained a share of the top of the Southeastern Conference, its 9-1 league mark their second-best in program history behind a 10-0 start in 1997. Sindarius Thornwell had 18 points and Duane Notice 15 for South Carolina. The seniors both had four three-pointers. J.J. Frazier and Yante Maten had 18 points apiece for Georgia (13-10, 4-6).
at No. 21 Duke 72, Pittsburgh 64: Grayson Allen scored 18 of his 21 points in the second half for the Blue Devils in Coach Mike Krzyzewski's return after a four-week break following back surgery.
Amile Jefferson added 15 points, freshman Jayson Tatum had 12 and Luke Kennard added 10 to help the Blue Devils (18-5, 6-4 Atlantic Coast Conference) win their third straight.
Michael Young scored 24 points and Jamel Artis added 17 for the Panthers (12-11, 1-9), who have lost eight straight but the ACC's last-place team gave its preseason favorite fits all game.
Xavier 82, at No. 22 Creighton 80: J.P. Macura scored 13 of his 15 points in the second half, and the Musketeers capitalized on their hot shooting late in the game and Bluejays' struggles at the free-throw line.
Xavier (17-6, 7-3 Big East) made seven of nine shots, including five three-pointers, during a 19-7 spurt that turned their 66-59 deficit into a 78-73 lead with two minutes left.