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Treat Your Pain with the Best Nerve Pain Supplements

  1. Nerve Renew Advanced Nerve Support
  2. Genius Neuropathy Pain Relief Cream
  3. Boiron Hypericum Perforatum
  4. Sciatica Nerve Pain Relief Supplement
  5. NeuropAWAY Nerve Support Formula Pain Relief
  6. RHP Nerve Support Formula
  7. Native Remedies SciatiGon-S
  8. Buyer's Guide

From nerve damage to spine conditions due to chronic diseases, there are many health issues that can cause nerve pain or neuropathy. Burning, stabbing, prickling, and tingling are some of the sensations you can experience when you feel nerve pain. It can be extremely uncomfortable and sometimes hard to bear if not controlled. In most cases, it is a generalized feeling most of the time with no clear source of pain, making it harder to cope with.

While there is no definitive cure for nerve pain, it can be treated. One of the more reliable ways to treat neuropathy is through nerve pain supplements because they can alleviate the symptoms and help with recovery. In this guide, we have reviewed the seven best nerve pain supplements of 2022 that can effectively relieve your nerve pain.

Comparing the Best Nerve Pain Supplement for 2022

Nerve Renew Advanced Nerve Support - Best Nerve Pain Supplement Overall

Nerve Renew Advanced Nerve Support is a popular pain relief supplement for diabetic patients. However, it is also suitable for treating acute and chronic inflammatory chronic issues, vitamin deficiency, Lyme disease, and other nerve damage conditions.

This neuropathy supplement contains potent ingredients like R-Alpha Lipoic Acid to improve the nerve blood supply and ease numbness and tingling. It provides vitamins D, B1, B2, B6, and B12 to supplement diet deficiencies. Nerve Renew claims to work three times faster, and is more effective and bioavailable than other nerve pain supplements because it contains benfotiamine, which the body absorbs quickly.

Genius Neuropathy Pain Relief Cream - Runner Up

If you need relief in your hands, feet, toes, or sciatic nerve, then Genius Neuropathy Cream is the supplement that will delight you. Its proven formula quickly relieves your pain while nourishing and moisturizing your skin.

This topical pain relief supplement contains clinically-tested high-quality ingredients like MSN, aloe vera, arnica, and vitamins E and B6. These powerful ingredients not only boost your blood circulation but also allow the cream to penetrate quickly into your skin, giving you quick and lasting relief. You don’t even have to apply much cream to the targeted area to get maximum comfort from the pain.

Boiron Hypericum Perforatum - Honorable Mention

Hypericum Perforatum is a homeopathic medicine made to treat nerve trauma and sharp, electric-like nerve pain in the back and legs. This unflavored medicine is easy to take as it quickly melts in your mouth without the need for water.

It contains around 80 tablets that instantly alleviate pain, thanks to its one pure active ingredient with no known drug interactions or other inactive ingredients like sucrose and lactose. Unlike other nerve pain supplements, this homeopathic medicine won’t make you drowsy.

Sciatica Nerve Pain Relief Supplement - Consider

Whether you have sciatica pain due to carrying heavy loads, driving long routes, or any other job entailing back twisting, Sciatica Nerve Pain Relief Supplement is the best option to ease your pain. These capsules effectively relieve numbing, shooting, and burning pain in your lower back, hip, and legs.

The formula of this supplement is made of clinically-studied natural ingredients that have no added milk, peanuts, fish, eggs, and more. Thus, these capsules are free of many common allergens. The powerful blend of non-chemical ingredients can effectively soothe, protect, and regenerate your nerves.

NeuropAWAY Nerve Support Formula Pain Relief - Best Nerve Pain Relief

NeuropAway pain relief supplement is perfect for alleviating swelling, burning, tingling, and numbness in your neck, hands, legs, and sciatic nerve. It boosts blood supply to nerve cells, improves nerve function, maintains uniform conduction velocity, and eases nerve pain symptoms quickly.

This supplement contains powerful ingredients like Taurine, R-Alpha Lipoic Acid, B-Alanine, Acetyl L-Carnitine, and more that support damaged nerves and have no side effects. Among all these ingredients, B-Alanine is the only one that differentiates this supplement from other pain relief medicines. It not only increases peripheral nerve sensitivity and excitability but also acts quickly and starts alleviating within 3-5 days of the start of treatment.

RHP Nerve Support Formula - Best Nerve Pain Relief

The Nerve Support Formula Supplement has been on the market for more than ten years. It's a perfect blend of ingredients that provides relief and nutritional support to people with neuropathy.

This supplement is focused on the notion that deficiency of vitamin B leads to nerve damage. That’s why it is rich in vitamin B1, B12, and B6. While vitamin B1 and B12 treat nerve health issues and heal damaged nerves, vitamin B6 supports your nerve cells, which build a complete multi-B complex that your body should absorb to get relief from pain.

Native Remedies SciatiGon-S - Best Nerve Pain Relief

Since your sciatic nerve runs from the lower back to the buttock and pelvis region, you may experience sciatic pain anywhere in this longest peripheral nerve. SciatiGon-S is a combination of five herbal, non-addictive ingredients that improve the health of your sciatic nerve and provide comfort. These ingredients include prickly ash, burdock, fresh skullcap, German chamomile, and devil’s claw.

This 100% safe, natural supplement is specifically formulated to calm muscle spasms, stiffness, and burning, tingling, or numbing sensations in your legs and toes. All in all, it is very easy to use - you simply need to add it to water or drop it into your mouth using the dropper.

Buyer's Guide

Best Nerve Pain Supplements Buying Guide

Nerve pain supplements are not an alternative to the conventional treatment but are an excellent addition as they have don’t have an array of side effects. Though they are harmless overall, you should consult your physician beforehand to ensure your medications don’t clash. This guide will help you know which products are best for your nerve pain.

Note: If you are experiencing nerve pain symptoms, we recommend you seek professional medical advice. The content presented here is for entertainment/informational purposes only and should not be construed as medical advice under any circumstances.

Which Ingredients Should You Consider While Purchasing the Best Nerve Pain Supplement?

Alpha Lipoic Acid

Alpha Lipoic Acid is an effective antioxidant that eliminates or reverses the impact of oxidative stress present in the nerve cells. The key behind the functioning of this antioxidant is the reduction of lipid peroxide in high glucose environments.

It helps enhance the activity of ATPase in nerve cells while reducing protein glycosylation, which improves the functioning of nerves. On top of that, Alpha Lipoic Acid boosts microcirculation in nerve tissues to provide adequate support and nutrition to the nerves.

B Vitamins

B Vitamins play a significant role in the maintenance of homeostasis in your body. They are beneficial for nerve repair, neuroprotection, neurogenesis, and nerve function recovery. In order to relieve nerve pain, they also act as anti-nociceptive and anti-inflammatory ingredients in a supplement.

Peripheral nerve pain is sometimes caused due to the deficiency of vitamins B1, B6, and B12, as they are essential for the health of our nervous system. While vitamin B1 is important to alleviate pain, vitamins B6 and B12 are vital for saving your brain nerves from damage.


Acetyl-L-Carnitine is a popular antioxidant as well as an active amino acid. The antioxidants help you maintain the redox balance in your body, promoting neuroprotective functions and the maintained balance of homeostasis in your body.

The active amino acids, on the other hand, play a significant role in conveying messages from the body to the brain and vice-versa. They help in making or increasing nerve cells that transmit messages.

Moreover, Acetyl-L-Carnitine controls the production of neurotoxins by reducing the number of lipid peroxides along with other free radicals in your nerves. Thus, it helps to boost energy levels, produce healthy cells, and heal nerve pain.


Almost all nerve pain supplements contain Capsaicin. It is basically C-fibers present in the nerves that stimulate the release of Substance P to help you provide pain relief.

N-Acetyl Cysteine

N-Acetyl Cysteine is an excellent antioxidant and a precursor amino acid. Like Acetyl-L-Carnitine, it also helps in balancing redox and maintaining homeostasis in our brain. It is responsible for the regeneration of the nerve cells that helps transmit messages from body to brain and vice-versa. Thus, it will improve your neuropathy conditions, reduce inflammation, and cope with nerve pain.

N-Acetyl Cysteine isn’t found naturally — it is an artificially-made ingredient incorporated into nerve pain supplements. Experts say that this component can be suitable for treating diabetic neuropathy due to its pain-relieving properties as well as improving motor function.


Curcumin is a common component that exists in almost all neuropathy supplements. It is usually extracted from turmeric, which contains ample healing and medicinal properties like pain relief, antioxidants, and anti-inflammatory abilities. That’s why South Asian nations use turmeric mixed with milk for alleviating joint pain. Basically, curcumin helps people with neuropathy get rid of numbness of the limbs and improve their motor functions.

Fish Oil

Omega-3, or fish oil, has been healing damaged nerves for centuries. This component is excellent when it comes to reducing muscle pain and soreness due to neuropathy conditions. Moreover, this oil has been tested by experts for its effect and significance on diabetic patients with neuropathy.

Fish oil is a slow-acting but effective component for reversing peripheral nerve pain in diabetic patients while eliminating pain, numbness, and discomfort they may have been experiencing in their limbs. This component not only expedites and stimulates the growth of nerve cells but also alleviates neuropathy symptoms considerably.


Magnesium is a component that helps with sensitization in people with nerve pain. It is generally known to prevent the channels or receptors that transmit N-methyl-D-aspartate. These receptors transduce the pain signals to our brain, generating an appropriate response.

Once magnesium enters your system, it doesn’t allow N-methyl-D-aspartate - a pain triggering component - to bind to the receptors, preventing the pain signals from reaching our brain. This component is widely used for relieving the pain of patients suffering from cancer, chemo-based peripheral neuropathy, and diabetic neuropathy.

Final Words

Neuropathy has ample causes, yet not a proper cure at the moment. Since it is often a painful, uncomfortable, and long journey, nerve pain supplements are here to facilitate your pain relief. They are not a hard and fast solution but are obviously beneficial enough to alleviate your pain and gradually improve the motor functions of your body. We hope this guide has enough information to help you find the best nerve pain supplement that meets your needs.

Nerve Pain Supplement FAQ

Do supplements really treat nerve pain or neuropathy?

Yes, nerve pain supplements are specially designed to alleviate the symptoms of neuropathy. They can effectively ease your pain, reduce numbness, and control the unpleasant sensations you experience.

Are nerve pain supplements safe?

Yes, most nerve pain supplements don’t have significant side effects. These medicines often contain few synthetic ingredients that function like dietary supplements.

Can I take nerve pain supplements even if I have no symptoms?

Yes, you can take these supplements if you have no symptoms, but it would be a good idea to use general dietary supplements. Nerve pain supplements are specific for treating neuropathy conditions.

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