The Burbank Police Department will set up a sobriety checkpoint near San Fernando Boulevard and Delaware Road on Friday, Sgt. Armen Dermenjian said.
Officers will randomly screen cars and administer field sobriety tests to drivers who appear under the influence of alcohol.
The checkpoint will begin at 6 p.m. and continue until 2 a.m., Dermenjian said.
In compliance with checkpoint regulations, a turnout will be provided for drivers to avoid the stop.
Between 15 and 20 officers are expected to participate in a cooperative effort with the Avoid the 40 Region Three DUI Task Force, including officers from Glendale, Pasadena, Monrovia and elsewhere.
The task force seeks to reduce alcohol-related accidents, injuries and fatalities through increased enforcement.
The Burbank Police Department's last sobriety checkpoint was on the 200 block of West Olive Avenue on Dec. 16, 2005.
The officers screened 1,000 cars, conducting three field sobriety tests and issuing one arrest for driving under the influence.