Set along a hillside, obscured by hedges and tall bamboo, the refreshed 1930s home features vaulted ceilings with exposed beams, bright artistic tile risers and a fireplace with a steel mantel. French doors open to a terrace patio that overlooks the grounds.
Among common areas is a living room with shelving made of reclaimed barn wood, a dining area, an eat-in kitchen and a wine cellar. A separate garage studio has polished concrete floors.
The master suite has an Art Deco-inspired tiled bathroom and a custom walk-in closet for a total of four bedrooms and three bathrooms in more than 1,900 square feet of space.
A long veranda with subtle arches and an outdoor kitchen extend off the main level of the house. Various patios, an outdoor living room, planters and exotic landscaping fill the brick-lined setting.
Segel bought the house a year ago from journalist Joel Stein for $1.4 million.
Mary Brill and Jane Gavens of John Aaroe Group hold the listing.
The 36-year-old Segel is known for his role as Marshall Eriksen on the long-running CBS sitcom. His film credits include "Forgetting Sarah Marshall" (2008), "I Love You, Man" (2009) and "The Muppets" (2011).
He's since moved on to a 1920s home formerly owned by street artist Shepard Fairey. The Mediterranean-style home, designed by architect H.B. Benson, features original ironwork, hand-plastered walls and a great room with vaulted ceilings.
He paid $2.25 million — $415,000 more than the asking price — for the 2,523-square-foot house.