The 4,088-square-foot house, built in 1962, features walls of glass, dark bamboo flooring, three fireplaces, four bedrooms and four bathrooms. The ocean-view home sits on 1.26 bluff-top acres with a tennis court, a lap pool and beach access.
Pitt, 48, starred last year in "Moneyball" and "The Tree of Life." He will star in the upcoming "Cogan's Trade" and "World War Z."
DeGeneres, 53, has hosted the show bearing her name since 2003. She listed her Beverly Hills compound for sale last year at $49 million and recently reduced the asking price on her 26-acre equestrian property in Thousand Oaks to $14.9 million.
Ellen Francisco of Coldwell Banker's Malibu West office listed the Malibu property for sale in August at $13.75 million, and it was withdrawn from the Multiple Listing Service last month. High-profile houses are sometimes withdrawn before a deal closes so the activity will not be reported in the MLS.