Eight Republicans joined all 13 Democrats on the Senate Finance Committee in endorsing Burwell, who is expected to easily be confirmed when her nomination is considered by the full Senate, likely next month.
Utah Sen. Orrin Hatch, the senior Republican on the committee, praised her Wednesday as an "excellent choice."
Sen. Johnny Isakson (R-Ga.) noted that although he does not support the healthcare law, he was confident that Burwell would be responsive to lawmakers. “I believe we’ll get answers,” he said.
Obama tapped her last month to replace Kathleen Sebelius, who has guided implementation of the Affordable Care Act for the last four years.