The Nuggets, like the Lakers, will not make the playoffs this season.
Former Lakers guard Brian Shaw was fired as head coach in March, replaced in the interim by Melvin Hunt.
If Lawson plays, the Lakers will have a challenge dealing with Denver's leading scorer (15.4 points a game) and playmaker (9.5 assists).
Jordan Clarkson just worked through a difficult pair of games against Chris Paul and the Clippers. The team swarmed Clarkson on the pick and roll, but after struggling on Sunday with just two points and three assists, the rookie notched 20 points and six assists Tuesday.
The Nuggets are not nearly the same defensive unit -- Clarkson may have a big game in Denver Wednesday.
Forward Kenneth Faried is an energy player for the Nuggets. On the season, he's averaging 12.0 points and 8.8 rebounds a game.
With the Lakers on a back-to-back, Faried might be a lot to handle for what could be a fatigued Lakers' squad.
The Lakers should be capable of beating the Nuggets, but the late night of travel combined with the high altitude of Denver may lead to a Lakers fade down the stretch.