Manu Ginobili scored on a layup with 18 seconds left, made a free throw with 9.1 to go and harassed James into a turnover with 1.9 seconds remaining for the defending
Anderson Varejao scored 23 points, Kyrie Irving added 20 and James 15 for the Cavaliers, who fell to 5-5.
James made only six of 17 shots. After Ginobili missed his free throw, James tried to rush the ball up the floor for a possible tying basket but lost control near mid-court.
Boston 101, at Philadelphia 90:
at Toronto 96, Memphis 92:
Dallas 105, at Washington 102:
at Indiana 88, Charlotte 86:
Phoenix 88, at Detroit 86: