A Soyuz space capsule blasted off Thursday for the International Space Station, carrying an American astronaut making his first space flight and a veteran Russian cosmonaut.
They were to travel six hours before docking at the space station.
Fischer and Yurchikhin will join NASA's Peggy Whitson, Russia's Oleg Novitskiy and France's Thomas Pesquet.
The two American astronauts are scheduled to speak with President Trump on Monday. On that day, Whitson, the first woman to command the International Space Station, will have spent 535 days in space, more time than any other American astronaut. Jeffrey Williams currently holds the record.
At 57, Whitson also is the oldest woman in space. She returns to Earth in September.
Fischer and Yurchikhin, making his fifth space flight, will spend more than four months aboard the orbiting station before also returning to Earth in September
1:35 a.m.: Updated with details on the astronauts.
12:40 a.m.: Updated with Soyuz reaching orbit.