Set on 2 acres in Fryman Estates and built in 1988, the main residence has floor-to-ceiling stone fireplaces in the living and family rooms and a formal dining room large enough to seat 16. Including staff quarters, the property has five bedrooms and 6 1/2 bathrooms in the 6,899 square feet.
The garage of 7,200 square feet houses a replica of Barbera's office at Hanna Barbera, multiple cars, an administrative office and storage.
An entertainment area is adjacent to the pool and spa. The estate also has a lighted tennis court.
Joseph Barbera died in 2006 at 95. He founded the Oscar- and Emmy-winning animation studio that bears his name in 1957 with William Hanna.
Sheila Barbera will be making her primary residence at her Old Las Palmas estate in Palm Springs.
Karen Misraje of Partners Trust, Beverly Hills, is the listing agent.