Kutcher took over the ousted celeb's spot on the CBS comedy in 2011 following Sheen's litany of public outbursts against the CBS series and its producer Chuck Lorre.
Though Sheen moved on to his FX show "Anger Management," the actor hasn't stopped bashing his replacement, most recently dubbing Kutcher a "lame side-kik" to costar John Cryer and beseeching him to "quit barfing on my old brilliant show."
And it appears Kutcher has had it. Appearing on "Jimmy Kimmel Live" on Wednesday, the "That 70s Show" alum called out the self-proclaimed warlock.
"Dude, shut the ... up!" the 35-year-old yelled, addressing the camera as if were Sheen. "Seriously, like, enough already. It's three years later and you're still blowing me up on Twitter? Come on, dude, really?"
The "Jobs" star and tech entrepreneur also joked that he was trying to "skew towards where Charlie was at when he left." Watch it above at about the 2:50 mark.
However, he did add that he finally felt at home on the show as Sheen's replacement, Walden Schmidt.
"We're in the third year I've been there now, and I feel like I'm at home," he told the host. Surely, it doesn't hurt that he and Cryer have become TV's highest-paid actors.
Sheen, 48, never one to take things sitting down, happened to catch the appearance and issued a public apology on Twitter following Kutcher's plea.
"Ashton message received," he tweeted. "so sorry u sounded like me! well done! my bad I was pissed at other crap & took it out on you. hope u r good xox c."
And all seemed well. For all of two hours. Then Sheen hurled another verbal assault at Kutcher. (Blame the tiger blood.)
"but news flash Dood, you ever tell me to shut the ... up, EVER again, and I'll put you on a hospital food diet for a year. c #YaFeelMe Jr?, he added.
Looks like this feud is still far from over...
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