Giuliana Rancic tells of surrogate's miscarriage, her own weight loss

Giuliana Rancic says she and Bill Rancic remain 'open to everything' after last embryo is lost to miscarriage

Giuliana Rancic has revealed another setback in her quest with husband Bill Rancic to have another child: Their surrogate miscarried their third and final embryo on New Year's Eve.

She also has revealed why she's so skinny -- more on that later.

"We thought, 'This is definitely going to work. This is our last shot,'" the E! personality told People about the pregnancy. Getting the bad news, especially after being so optimistic, was painful, she said.

The Rancics had two embryos successfully implanted in their surrogate Delphine last year, and dealt with another miscarriage last June. This miscarriage happened about nine weeks into the pregnancy and left the couple "devastated," she said.

Delphine is the one who helped them welcome son Duke, who turns 3 at the end of August. Pregnancy would be dangerous for Giuliana, 40, who discovered in 2011 that she had early-stage breast cancer and underwent a double mastectomy and reconstruction soon after.

Then 36, she'd had a mammogram at her fertility doctor's urging, sooner than she would have otherwise. The "Fashion Police" panelist, whose show has been put on ice until September, credited her then-future baby with saving her life.

Now, however, the cancer-suppressing medication she's on has affected her metabolism, rendering her that skinny despite what she described as a healthy appetite and a robust diet. She eats more than all of her friends, she said, and has dessert almost every night.

No eating disorder, Rancic said. No return of the cancer.

"I'm sorry that some people think I'm disgustingly skinny, as they put it, but there's nothing I can do," she told People. "I'm lucky that I even have the type of cancer that reacts to the medicine."

In terms of expanding their family despite having no embryos left, Rancic said they're still "open to everything."

"It's funny, I'm even more open to [adoption] than I was before. Because I think to myself, 'I love Duke so much, if I couldn't take care of him, I hope there would be someone else who would love him.'"

Follow Christie D'Zurilla on Twitter @theCDZ and Google+. Follow the Ministry of Gossip on Twitter @LATcelebs.

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