The three actors wrapped up filming in Uruguay on Wednesday on the story of an unnamed city where everyone suddenly loses their eyesight, and the chaos that ensues.
Moore's character is the only one unaffected by the epidemic in the movie, based on a novel by Portuguese writer Jose Saramago.
"When you are blind you try to adopt another kind of sensitivity, so this role is definitely a challenge from a physical point of view," said Glover, 60, from the Uruguayan capital of Montevideo.
"The story is powerful and it addresses how we relate to each other as human beings," he said.
The three actors took time out to dance a tango, buy souvenirs and drink mate, a tealike infusion sipped with a metal straw.
The production heads to Brazil on Friday, where "Blindness" director Fernando Meirelles first won fame for "City of God," which depicts life in a Rio de Janeiro shantytown.