And that one didn't last long.
Federer, racing against Father Time to win an eighth title here, sent Gilles Muller of Luxembourg out in straight sets, 6-3, 7-5, 6-3. Federer joined other marquee stars in making easy advances.
Only top-seeded Rafael Nadal struggled, beating unseeded Lukas Rosol of the Czech Republic after being down a set and a break at 4-1 of the second.
Serena Williams, top-seeded in the women's tournament, played on Court 1 at the same time Nadal was on Centre Court, and was gone before he broke a sweat. Williams beat Chanelle Scheepers of South Africa, 6-1, 6-1.
Williams said she is hoping to ease her way into the tournament.
"I don't want to feel great, necessarily, right now," she said, "because hopefully I have several more matches to play."
As has been the tendency in recent major tennis events, 6-foot-10 John Isner is the last U.S. men's player standing. He got to the third round with a 7-6 (17), 7-6 (3), 7-5 victory over Jarkko Nieminen of Finland.
Isner hit 32 aces in the match, including 17 in the long first set.