Forward Tobias Harris was a force for the Magic, finishing with 28 points and 20 rebounds. Former UCLA guard Arron Afflalo had 23 points and six assists while point guard Jameer Nelson contributed 22 points and six assists.
The Lakers held leads after the first (28-22) and second quarters (55-53) but fell apart in the third, giving up 38 points to trail by 11 points, 91-80, entering the fourth quarter and never recovered.
Power forward Pau Gasol led the Lakers with a double-double, scoring 21 points, grabbing 11 rebounds and dishing six assists. Point guard Kendall Marshall also had a double-double with 19 points and 14 assists.
Offensively the Lakers were solid, shooting 45.6% from the field and 54.5% from three-point range. They had only 11 turnovers, including none in the first quarter.
As has often been the case this season, the Lakers didn't get the job done defensively.
The Magic shot 48.1% from the field and 52.9% from long range, while doubling up the Lakers on free-throw attempts, 34 to 17. Orlando's 27 made free throws were 10 more than attempted by the Lakers, who made 11.Five Lakers scored in double figures: Jodie Meeks (17), Nick Young (16), Ryan Kelly (15), Gasol and Marshall.
The Magic also got 15 points and 12 rebounds from rookie guard Victor Oladipo. Center Nikola Vucevic sat out with a concussion. The Lakers played without Kobe Bryant (knee), Steve Nash (back), Steve Blake (elbow), Jordan Farmar (hamstring) and Xavier Henry (knee).
The Lakers finish up their seven-game road trip on Sunday in New York against the Knicks (15-27).
Orlando also plays on Sunday, visiting the New Orleans Pelicans (16-25).
As they've been prone to do over recent weeks, the Lakers fell apart in the third quarter.
With 9:24 left in the quarter, Jodie Meeks hit a three-pointer to give the Lakers a 65-55 advantage. The Magic would go on to outscore the Lakers, 36-15, to the quarter ahead by 11 points.
The Lakers were led byMeeks with 17. Point guard Kendall Marshall had a double-double with 13 points and 12 assists, but the Lakers shot only 42.5% from the field.
Orlando took 26 free throws, making 20, while the Lakers attempted just 11, making eight.
The Lakers did shoot well from three-point range, hitting 10 of 17 (58.8%). The Magic weren't too far behind at 53.8% (7 of 13).
The Lakers pushed their lead to eight points in the second quarter but the Magic charged back, scoring 13 unanswered points to take a five-point lead.
A late three-point shot from forward Wesley Johnson returned the lead to the Lakers heading into halftime.