Busch fell about 200 miles short of completing the 1,100 miles of racing, known as "The Double," when his engine blew more than a third of the way through the NASCAR Sprint Cup Series race.
"It acted like it swallowed three cylinders all at once," Busch said of his engine failure. "It's kind of a shame. It symbolizes how tough it has been for the team. I thought it was great racing in traffic. The feel of the stock car right after driving the IndyCar is a feeling I'll never forget.
"Those things happen in motor sports. It was a good battle, though. I was hoping to do 1,100 miles today. I can't let what happened here dampen the mood of what happened in Indianapolis."
Busch was the fourth driver to attempt the IndyCar/NASCAR double. The last driver to attempt it was
The only driver to complete both races is
Busch's plan fell into place when the Indy 500 was completed with only a few crashes to delay the race. He hopped on a helicopter out of Indianapolis Motor Speedway and then got on a plane bound for Charlotte.
Patricia Driscoll, Busch's girlfriend, posted a photo on her Twitter page of Busch taking a nap alongsid her son while receiving fluids in preparation for the Coca-Cola 600.
Driscoll's latest tweet said, "A fast flight between races for #DoubleOutlaw on the Cessna Citation X." She included a photo of Busch lacing up his shoes while already in his driver's suit.
"It was an incredible journey to sniff the lead of the Indy 500," Busch said.