Obesity Research

Why yo-yo dieters often can't keep the weight off

Why yo-yo dieters often can't keep the weight off

For those who have lost the same 10, 20 or 50 pounds not once but many times over, new research may help explain why yo-yo dieters so often fail to maintain their hard-won weight loss. 

The community of microorganisms that inhabit the gut are a key culprit, experiments in mice suggest. After being altered by obesity, this collection of bacteria, viruses and protozoa — collectively known as the gut microbiome — subverts any effort to keep lost weight off. Instead, it seems to encourage the body to...

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