Cris “Cyborg”Justino will defend her
Costa Mesa-trained Justino (17-1) won the belt in the division effectively created for her in July when she defeated Tonya Evinger by third-round knockout.
Previous champion Germaine de Randamie was stripped of the featherweight belt she won in February by defeating Holm in a disputed decision.
In that fight, De Randamie twice struck Holm (11-3) with punches after the bell but avoided a point deduction.
De Randamie then balked at fighting Justino, citing the Brazilian's failure of a drug test.
Holm returned in June to knock out previous bantamweight title challenger Bethe Correia.
Holm, a former pro boxer from Albuquerque, knocked out Ronda Rousey in Australia two years ago this week.
Holm's ability to prevail in most slugfests provides a compelling angle to her showdown against Justino, a devastating striker.
UFC 219 is a pay-per-view card that will be staged at T-Mobile Arena.