The Clippers, who led by as many as 19 points, outshot the Wizards, 52.3% to 43%, outrebounded them, 46-36, and made twice as many three-pointers -- 12 to the Wizards' six.
The Clippers have won three of their four games since Griffin returned.
Matt Barnes, who started Friday after missing the last two games because of soreness in his right hamstring, struggled a bit, scoring eight points on three-for-10 shooting in 30 minutes.
It was Jamal Crawford's birthday Friday, but the reigning sixth man of the year missed his ninth game because of a bruised right calf.
The Clippers (45-25) are in fifth place in the Western Conference, only half a game behind the fourth-place
The Wizards (40-29) are in fifth place in the East.