Gabe York scored 16 points, Brandon Ashley added 13 and No. 6
The Wildcats had their way inside and out in one of their best offensive performances of the season, shooting 59% while outscoring the Ducks, 44-18, in the paint.
"That was one of our best games all year," Arizona point guard T.J. McConnell said.
It was Arizona's 33rd straight victory at home.
Elgin Cook had 16 points and Joseph Young added 12 for Oregon.