Bryant has sat out three of the last four games to rest. The Heat has struggled in the Eastern Conference, but was able to upset the Clippers on Sunday.
The pair have played well this season, but both missed eight games with various injuries.
At full strength, Miami is dangerous.
Tarik Black has seemingly overtaken Robert Sacre in the rotation. Black, Sacre and Carlos Boozer may also get time against Bosh.
Miami's Hassan Whiteside had a career night against the Clippers on Sunday, scoring 23 points with 16 rebounds.
If Whiteside can emerge as a steady low-post threat, allowing Bosh to play more of a high-post, face-up game, the Heat may climb in the Eastern Conference standings.
Nick Young has found himself in a massive shooting slump through the past week or so. The Lakers need his offensive punch.
The Heat is a dangerous team, and probably favored here given how hot and cold the Lakers have been this season.
Despite that, put the Lakers down for the win Tuesday at Staples Center.