The Lakers (5-13) have yet to lose a game this season to the Eastern Conference (4-0). They will face their toughest test to date Wednesday night, visiting the Washington Wizards (11-5) after a victory Tuesday in Detroit over the Pistons, 106-96.
The Wizards are one of the top teams in the East, sitting in second place behind the Toronto Raptors (14-4), whom the Lakers upset Sunday at Staples Center.
Washington has a balanced roster led by point guard John Wall, who is averaging 18.2 points and 9.3 assists a game.
The Lakers did an excellent job defending against Brandon Jennings on Tuesday, but Wall is a tougher cover.
Jeremy Lin will be charged with defending against the Wizards' point guard, who is shooting 43.3% from the field and 33.3% from behind the arc.
Wall is less of a threat from distance, instead using his speed and athleticism to attack and create.
Lin is averaging 12.4 points with 5.1 assists while shooting 47.2% from the field and 37.5% from three-point range.
Both guards can be turnover prone, Wall at 3.6 a night and Lin at 2.6.
Pierce is a longtime rival of the Lakers dating to his days with the Boston Celtics.
If the game is close, the 37-year-old Pierce can still hit a big shot.
Hill has become one of the Lakers' most important players this season, averaging 14 points and 9.7 rebounds a game.
The Lakers are slightly better than their record shows, but not good enough to get the Wizards on the right half on the second night of a back-to-back.