On the road Monday, they'll visit the Golden State Warriors (52-13).
The Lakers previously upset the Warriors in late December, with a 115-105 victory in which seven Lakers scored in double figures.
Stephen Curry scored 22 points in the losing effort, but turned the ball over seven times.
Center Andrew Bogut sat out with injury, but the Warriors now are at full strength, while the Lakers bring a skeleton crew.
Curry is an extremely gifted shooter and ballhandler. He's surrounded by excellent players, including backcourt mate Klay Thompson.
Clarkson is still learning how to play point guard at the NBA level, averaging 9.5 points and 2.5 assists a game on the season while shooting 42.7% from the field.
Curry is at 23.6 and 7.8, shooting 48.3% from the field, 42.2% from three-point territory.
Thompson almost always seems to have big games against the Lakers. The Warriors also have a do-it-all forward in Draymond Green who can defend at multiple positions, rebound, score and pass -- whatever is needed for the team.
Golden State scores 109.7 points a night while yielding just 99.5.
The Lakers give up 105.1 while managing just 98.9 offensively.
For the Lakers to have a shot, they'll need big games from guards Jeremy Lin and Wayne Ellington -- both capable scorers when they get hot.
The Warriors won't lose another game to the Lakers -- Dec. 23 was an aberration.