Seau is the 12th former USC player to be inducted into the Hall of Fame, joining Frank Gifford, Ron Mix, Red Badgro, O.J. Simpson, Willie Wood, Anthony Munoz, Ronnie Lott, Lynn Swann, Ron Yary, Marcus Allen and Bruce Matthews.
Seau, who committed suicide in 2012 at age 43, played at USC in 1988 and 1989. He was an All-American in 1989.
The San Diego Chargers selected Seau with the fifth overall pick in the 1990 draft. He played for the Chargers, the Miami Dolphins and the New England Patriots and appeared in two Super Bowls during his 20-year career.
Seau was the 1992 NFL defensive player of the year.
The 2015 Hall of Fame class will be enshrined on Aug. 8 at Canton, Ohio.