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University of Cambridge
Of mice and men: Researchers point to differences in cell development
Of mice and men: Researchers point to differences in cell development

Scientists say they have discovered a key factor in the lab formation of human primordial germ cells -- the precursors to egg and sperm -- and that it differs significantly from experiments involving rodent cells. In a paper published Wednesday in the journal Cell, researchers at the University of Cambridge in England and the Weizmann Institute of Science in Israel said their discovery raises questions about how much mouse experiments can tell us about early human cell development. The research, according to study authors, suggests that "mechanisms of early cell fate decisions in mice cannot be safely or wholly extrapolated to specification events during early human...

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