The Lakers (9-35) draw the red-hot San Antonio Spurs (37-6) on Friday night at Staples Center.
The Spurs won their 12th consecutive game Thursday by beating the Phoenix Suns. San Antonio is only two games behind the Golden State Warriors (39-4).
Meanwhile, the Lakers are in last place in the Western Conference, losers of four in a row.
Larry Nance Jr. is not expected to play because of a sore knee, while Kobe Bryant (Achilles tendon and shoulder) and Brandon Bass (foot) are probable.
San Antonio regularly rests players; Tim Duncan sat out Thursday's game. Tony Parker is trying to work through a hip injury.