This time the problem is in the key itself, and affects about 3.16 million vehicles, most built between 2000 and 2011.
The car company said the keys, when jostled, may cause the cars to move out of the "run" position, which could disable features related to braking, steering and air bag deployment.
Eight crashes and six injuries have been related to this recall problem, GM said.
The affected vehicles are the Chevrolet Impala, years 2006 to 2014; plus certain Buicks built between 2004 and 2009, Cadillacs built between 2004 and 2011, and the Chevy Monte Carlo, built between 2006 and 2008.
The recall, GM says, is the result of ignition key inspections that followed a similar recall of 2.6 million Cobalts and other small cars.
Of the affected vehicles, only the Impala is still in production.
GM says it will replace the keys on all these vehicles, and announced five other smaller recalls:
More than 68,000 Cadillac ATS and CTS sedans, model years 2013 and 2014, may have shift cable problems.
Also, gasket leaks may occur on 16,000 2011 Cadillac CTS sedans with all-wheel drive.
More than 57,000 Chevy Silverado and GMC Sierra trucks, model year 2015, may have power steering pump issues.
About 200 model year 2014-15 Silverados and Sierras may also have loose floor mats.
About 700 2014 Chevy Corvettes could have seat belts that block passenger side air bags.