The Mavericks outshot the Clippers from the field, 60.7% to 50%, and from beyond the three-point line, 57.1% to 37.5%.
The Clippers had a 24-21 lead over Dallas after the first quarter, but they were outscored in each quarter thereafter, including by 17 points, 38-21, in the fourth.
The Clippers' starters were taken out of the game with seven minutes 18 seconds left and the Clippers down, 110-83.
J.J. Redick led the Clippers with 17 points on six-for-14 shooting. DeAndre Jordan had 16 points and 18 rebounds, while Matt Barnes added 14 points.
The Clippers were playing without Blake Griffin (right elbow) and Jamal Crawford (right calf bruise).
The Mavericks, who entered Friday's game having lost five of their last seven, were led by Chandler Parsons, who had 22 points, making five of his six three-point attempts. Charlie Villanueva added 19 points.
The Clippers had won both of their previous games against Dallas this season -- a 115-98 victory on Feb. 9 and a 120-100 win on Jan. 10. If the Clippers had won Friday, they would have swept their season series against the Mavericks for the first time in 21 years.
The Clippers ended their road trip with a record of 1-1 after beating the Oklahoma City Thunder on Wednesday, 120-108.
With the loss, the Clippers, who are in fifth place in the Western Conference, fell to 42-24, one-half game ahead of the sixth-place Mavericks (42-25).
The Clippers now return home to host the Houston Rockets on Sunday.