The Cavaliers pulled ahead early to double digits. The Lakers threatened multiple times throughout the game, including a brief fourth-quarter run to close to within eight, but their defense was an issue for most of the night.
Kyrie Irving led all scorers with 35 points.
Lou Williams was the high man for the Lakers with 28 points.
Bryant and James embraced when the Lakers veteran left the game in the final minute. Bryant received a rousing ovation from the Cleveland crowd.
Coach Byron Scott gave Metta World Peace some rare minutes. The veteran was rusty, missing seven of eight shot attempts.
Kevin Love suffered an injured shoulder in the game, sitting out the second half.
The Lakers (11-44) are off until Feb. 19, when they'll host the