After losing to the San Antonio Spurs, 108-95, on Friday, the Lakers will play their second game in as many days, hoping to break a five-game losing streak.
The Trail Blazers are still within reach of the eighth-place Sacramento Kings (19-23) in the Western Conference standings.
Lakers rookie Larry Nance Jr. has sat out recent games because of a sore knee. Portland, meanwhile is at full strength.
Lillard is also strong playmaker, averaging 7.0 assists a game.
It's his outside shooting that always seems to burn the Lakers. So far this season, Lillard is shooting 37.3% from behind the three-point arc.
Guard C.J. McCollum has also emerged as a big-time scorer for the Trail Balzers, averaging 20.7 points a game.
The Lakers' best regular three-point shooter is Williams (33.3%), who is actually matched by Nance (albeit with a low volume of attempts). Russell is shooting 32.4% from long range, Clarkson 31.7% and Kobe Bryant just 25%.
Nick Young (35.4%) and Metta World Peace (37%) have not played a part recently in the team's regular rotation.
The Lakers rarely seem to win in Portland and are less likely to do so on the second night of back-to-back games.