Hart was the only Villanova (10-0) player to score in double figures. He made 10 of 14 shots from the field, including three of four from behind the arc, and he made all 14 of his free throws.
Matt Farrell and Steve Vasturia had 18 points each for Notre Dame (9-1), which entered the game as one of eight remaining unbeaten Division I teams.
Villanova took its first lead of the game at 57-56 after Eric Paschall blocked Vasturia's three-pointer with 9:15 left. Hart assisted on a layup by Jalen Brunson at 9:09 to give the Wildcats the lead.
The teams exchanged the lead from there until Villanova pulled away in the final minute.
Farrell made his first six shots, including a driving layup at the halftime buzzer that gave Notre Dame a 41-36 lead.
at No. 16 Butler 75, No. 22 Cincinnati 65: Kelan Martin came off the bench to score 20 points and was the catalyst in two key second-half runs that helped the Bulldogs (9-1) rebound from their first loss of the season by extending their home winning streak against non-conference opponents to 34 games. Troy Caupain scored a season-high 22 points to lead the Bearcats (7-2) and Gary Clark added 16, also a season high.
at No. 3 Kansas 89, Nebraska 72: Frank Mason III had 18 points and seven assists without a turnover, Josh Jackson and Svi Mykhailiuk added 15 points apiece and the Jayhawks (9-1) had no trouble with their old conference foe despite playing without forward Carlton Bragg Jr., who is suspended indefinitely. Bragg was charged Friday with misdemeanor battery. Tai Webster led Nebraska (5-5) with 22 points. Ed Morrow Jr. finished with 16.
No. 5 Duke 94, at UNLV 45: Grayson Allen shot 75% from the field — including a perfect seven of seven in the second half — en route to a career-high 34 points to lead Duke in the first college basketball game ever played at T Mobile Arena. Luke Kennard had 16 points and five rebounds for the Blue Devils (10-1). The Rebels (5-4) tried to make a couple of runs to challenge Duke, getting as close as 38-26 late in the first half after an 8-0 spurt. Jalen Poyser had 16 points for UNLV.
at No. 8 Gonzaga 61, Akron 43: Przemek Karnowski scored 14 points and Gonzaga beat Akron in a defensive battle, lifting the Zags to the best start in program history. Nigel Williams-Goss added 11 points for Gonzaga (10-0), which has won 10 straight to open the season for the first time since joining Division I in 1958. Isaiah Johnson scored 11 points, and Jimond Ivey had 10 for Akron (7-3).
at No. 9 Indiana 103, Houtson Baptist 61: James Blackmon Jr. scored 18 points and Robert Johnson added 16 for the Hoosiers, who outrebounded Houston Baptist, 45-31. The Hoosiers (8-1) ran their offense with a heavy emphasis on ball movement, tallying a total of 19 assists on 33 field goals. The Huskies (3-5) trailed Indiana by as many as 42 points.
at No. 11 Louisville 102, Texas Southern 71: Quentin Snider scored 15 points, V.J. King added 13 and No. 11 Louisville overcame a cold shooting start to give Hall of Famer Rick Pitino his 400th victory as the Cardinals' coach. Donovan Mitchell had 12 points, Jaylen Johnson and Deng Adel 11 each and Mangok Mathiang 10 for Louisville (9-1). Freshman point guard Demontrae Jefferson debuted with 27 points for Texas Southern (4-5), which lost its fourth straight.
at No. 13 Xavier 77, Utah 69: J.P. Macura emerged from his shooting slump by scoring 18 points and RaShid Gaston helped the Musketeers get the edge up front against the nation's top rebounding team. Xavier (8-2) was coming off back-to-back road losses that featured long scoring droughts. Gaston had 11 points and 14 rebounds, helping Xavier to a 33-28 edge on the boards. The Utes (6-2) came in averaging 47.7 rebounds per game.
at No. 15 West Virginia 90, VMI 55: Daxter Miles Jr. scored a season-high 20 points and West Virginia overcame an early lull to give Coach Bob Huggins his 799th career win. West Virginia (8-1) followed up a 53-point win over Western Carolina on Wednesday night with a lackluster first half to finish its final exams week. QJ Peterson scored 17 points for VMI (1-7), which was limited to three field goals over the final 12 minutes of the game.
No. 17 Wisconsin 93, Marquette 84: Bronson Koenig scored 18 points, and Ethan Happ scored all 11 of his in the second half for the Badgers (9-2), who went on a 16-0 run in the second half to help build an 18-point lead with 6:44 left. Marquette (7-3) got within eight with 2:22 left but never seriously threatened the rest of the way. Markus Howard led Marquette with 22 points.
at No. 18 Purdue 77, Cleveland State 53: Isaac Haas scored 14 points, Caleb Swanigan had 13 points and 10 rebounds and Dakota Mathias added 12 points on four three-pointers for the Boilermakers (8-2), who finished the first half on a 12-0 run to lead 41-20 and never were threatened thereafter, leading by as many as 27 points in the second half. Bobby Word had 14 points to lead Cleveland State (3-6), which shot only 26.7 percent (8 of 30) during the pivotal first half.
No. 20 Arizona 79, at Missouri 60: Rawle Alkins had 19 points and nine rebounds for the Wildcats, while Kobi Simmons had 19 points and Kadeem Allen added 17 points, seven rebounds and four assists. Arizona (8-2) built a 25-8 lead in the first half. The Tigers (5-4) eventually cut the deficit to 45-41 early in the second half but Arizona responded with a 26-4 run that included a Missouri scoring drought of 6:59. Kevin Puryear had 11 points and seven rebounds for Missouri.